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Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal instability. Whereas in some tumors the aneuploidy occurs by missegregation of one or a few chromosomes, aneuploidy can also arise dur...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Kuznetsova, Anastasia Y, Seget, Katarzyna, Moeller, Giuliana K, de Pagter, Mirjam S., de Roos, Jeroen A D M, Dürrbaum, Milena, Kuffer, Christian, Müller, Stefan, Zaman, Guido J R, Kloosterman, Wigard P, Storchová, Zuzana
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614355/
https://ncbi.nlm.nih.gov/pubmed/26151317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1068482
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