Developmental origin, functional maintenance and genetic rescue of osteoclasts

Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure(1–9), whereas excess activity can contribute to bone los...

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Publicado no:Nature
Main Authors: Jacome-Galarza, Christian E., Percin, Gulce I., Muller, James T., Mass, Elvira, Lazarov, Tomi, Eitler, Jiri, Rauner, Martina, Yadav, Vijay K., Crozet, Lucile, Bohm, Mathieu, Loyher, Pierre-Louis, Karsenty, Gerard, Waskow, Claudia, Geissmann, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910203/
https://ncbi.nlm.nih.gov/pubmed/30971820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1105-7
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