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Regulation of lysosome biogenesis and functions in osteoclasts

In order to resorb the mineralized bone extracellular matrix, the osteoclast relies on the generation of a resorption lacuna characterized by the presence of specific proteases and a low pH. Hence, bone resorption by osteoclasts is highly dependent on lysosomes, the organelles specialized in intra-...

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Detalhes bibliográficos
Main Authors: Lacombe, Julie, Karsenty, Gérard, Ferron, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899188/
https://ncbi.nlm.nih.gov/pubmed/23966172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25825
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