A RANKL–PKCβ–TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

Bone resorption by osteoclasts requires a large number of lysosomes that release proteases in the resorption lacuna. Whether lysosomal biogenesis is a consequence of the action of transcriptional regulators of osteoclast differentiation or is under the control of a different and specific transcripti...

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Bibliografiske detaljer
Main Authors: Ferron, Mathieu, Settembre, Carmine, Shimazu, Junko, Lacombe, Julie, Kato, Shigeaki, Rawlings, David J., Ballabio, Andrea, Karsenty, Gerard
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650231/
https://ncbi.nlm.nih.gov/pubmed/23599343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.213827.113
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