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A RANKL–PKCβ–TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
Bone resorption by osteoclasts requires a large number of lysosomes that release proteases in the resorption lacuna. Whether lysosomal biogenesis is a consequence of the action of transcriptional regulators of osteoclast differentiation or is under the control of a different and specific transcripti...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650231/ https://ncbi.nlm.nih.gov/pubmed/23599343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.213827.113 |
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