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GGCX and VKORC1 inhibit osteocalcin endocrine functions
Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition. Before being secreted by osteoblasts in the bone extracellular matrix, OCN is γ-carboxylated by the γ-carboxylase (GGCX) on three glutamic acid resid...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4362468/ https://ncbi.nlm.nih.gov/pubmed/25753038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201409111 |
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