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Using Gene Editing to Establish a Safeguard System for Pluripotent Stem-Cell-Based Therapies
A major challenge in using human pluripotent stem cells (hPSCs) in therapy is the risk of teratoma formation due to contaminating undifferentiated stem cells. We used CRISPR-Cas9 for in-frame insertion of a suicide gene, iC9, into the endogenous SOX2 locus in human embryonic stem cell (ESC) line H1...
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| Yayımlandı: | iScience |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6909005/ https://ncbi.nlm.nih.gov/pubmed/31821946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.11.038 |
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