Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (tumors arising from undifferentiated hPSCs), unwan...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Martin, Renata M., Fowler, Jonas L., Cromer, M. Kyle, Lesch, Benjamin J., Ponce, Ezequiel, Uchida, Nobuko, Nishimura, Toshinobu, Porteus, Matthew H., Loh, Kyle M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264334/
https://ncbi.nlm.nih.gov/pubmed/32483127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16455-7
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