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Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (tumors arising from undifferentiated hPSCs), unwan...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7264334/ https://ncbi.nlm.nih.gov/pubmed/32483127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16455-7 |
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