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Integration-defective lentiviral vector mediates efficient gene editing through homology-directed repair in human embryonic stem cells
Human embryonic stem cells (hESCs) are used as platforms for disease study, drug screening and cell-based therapy. To facilitate these applications, it is frequently necessary to genetically manipulate the hESC genome. Gene editing with engineered nucleases enables site-specific genetic modification...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389720/ https://ncbi.nlm.nih.gov/pubmed/27899664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1057 |
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