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Site-specific Gene Insertion Mediated by a Cre-loxP-carrying Lentiviral Vector
Retroviral vectors have been used to treat patients with the X-linked severe combined immunodeficiency disease and chronic granulomatous disease. In both cases, success has been undermined by clonal expansion of transduced cells in some patients due to insertional mutagenesis induced by random vecto...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951562/ https://ncbi.nlm.nih.gov/pubmed/20628360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.150 |
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