Site-specific Gene Insertion Mediated by a Cre-loxP-carrying Lentiviral Vector

Retroviral vectors have been used to treat patients with the X-linked severe combined immunodeficiency disease and chronic granulomatous disease. In both cases, success has been undermined by clonal expansion of transduced cells in some patients due to insertional mutagenesis induced by random vecto...

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Bibliographic Details
Main Authors: Michel, Gilles, Yu, Yin, Chang, Tammy, Yee, Jiing-Kuan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951562/
https://ncbi.nlm.nih.gov/pubmed/20628360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.150
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