Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs) for B-lineage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory disease. The therapeutic index of this emerging modality is attenuated by th...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gardner, Rebecca A., Ceppi, Francesco, Rivers, Julie, Annesley, Colleen, Summers, Corinne, Taraseviciute, Agne, Gust, Juliane, Leger, Kasey J., Tarlock, Katherine, Cooper, Todd M., Finney, Olivia C., Brakke, Hannah, Li, Daniel H., Park, Julie R., Jensen, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908832/
https://ncbi.nlm.nih.gov/pubmed/31697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001463
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