Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs) for B-lineage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory disease. The therapeutic index of this emerging modality is attenuated by th...

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Vydáno v:Blood
Hlavní autoři: Gardner, Rebecca A., Ceppi, Francesco, Rivers, Julie, Annesley, Colleen, Summers, Corinne, Taraseviciute, Agne, Gust, Juliane, Leger, Kasey J., Tarlock, Katherine, Cooper, Todd M., Finney, Olivia C., Brakke, Hannah, Li, Daniel H., Park, Julie R., Jensen, Michael C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908832/
https://ncbi.nlm.nih.gov/pubmed/31697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001463
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