Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs) for B-lineage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory disease. The therapeutic index of this emerging modality is attenuated by th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Gardner, Rebecca A., Ceppi, Francesco, Rivers, Julie, Annesley, Colleen, Summers, Corinne, Taraseviciute, Agne, Gust, Juliane, Leger, Kasey J., Tarlock, Katherine, Cooper, Todd M., Finney, Olivia C., Brakke, Hannah, Li, Daniel H., Park, Julie R., Jensen, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Immunobiology and Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908832/
https://ncbi.nlm.nih.gov/pubmed/31697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001463
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge