Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs) for B-lineage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory disease. The therapeutic index of this emerging modality is attenuated by th...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Gardner, Rebecca A., Ceppi, Francesco, Rivers, Julie, Annesley, Colleen, Summers, Corinne, Taraseviciute, Agne, Gust, Juliane, Leger, Kasey J., Tarlock, Katherine, Cooper, Todd M., Finney, Olivia C., Brakke, Hannah, Li, Daniel H., Park, Julie R., Jensen, Michael C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2019
Aiheet:
Immunobiology and Immunotherapy
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908832/
https://ncbi.nlm.nih.gov/pubmed/31697826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001463
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