IMMU-02. CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL NEUROTOXICITY CORRELATES WITH PRETREATMENT AND ACUTE CSF NEUROFILAMENT LIGHT CHAIN (NFL) LEVELS

OBJECTIVE: Immunotherapy for hematologic malignancies with CD19-directed CAR T cells is complicated by neurotoxicity in approximately 40% of patients. We have previously reported evidence of glial injury in pediatric patients with CAR T neurotoxicity by elevated CSF levels of GFAP and S100b. We now...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Gust, Juliane, Wilson, Ashley, Finney, Olivia, Hartsuyker, Kendra Jae, Narayanaswamy, Prabha, Wu, Vicky, Garden, Gwenn, Annesley, Colleen, Gardner, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715669/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.359
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