The histone deacetylase SIRT6 restrains transcription elongation via promoter- proximal pausing

Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA Polymerase II (Pol II) pauses before proceeding towards productive elongation. The role of chromatin in pausing remains poorly understood. Here, we demonstrate that the histone deacetyl...

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Publicado no:Mol Cell
Main Authors: Etchegaray, Jean-Pierre, Zhong, Lei, Li, Catherine, Henriques, Telmo, Ablondi, Eileen, Nakadai, Tomoyoshi, Van Rechem, Capucine, Ferrer, Christina, Ross, Kenneth N., Choi, Jee-Eun, Samarakkody, Ann, Ji, Fei, Chang, Andrew, Sadreyev, Ruslan I., Ramaswamy, Sridhar, Nechaev, Sergei, Whetstine, Johnathan R., Roeder, Robert G., Adelman, Karen, Goren, Alon, Mostoslavsky, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
https://ncbi.nlm.nih.gov/pubmed/31399344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.034
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