The histone deacetylase SIRT6 restrains transcription elongation via promoter- proximal pausing

Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA Polymerase II (Pol II) pauses before proceeding towards productive elongation. The role of chromatin in pausing remains poorly understood. Here, we demonstrate that the histone deacetyl...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Etchegaray, Jean-Pierre, Zhong, Lei, Li, Catherine, Henriques, Telmo, Ablondi, Eileen, Nakadai, Tomoyoshi, Van Rechem, Capucine, Ferrer, Christina, Ross, Kenneth N., Choi, Jee-Eun, Samarakkody, Ann, Ji, Fei, Chang, Andrew, Sadreyev, Ruslan I., Ramaswamy, Sridhar, Nechaev, Sergei, Whetstine, Johnathan R., Roeder, Robert G., Adelman, Karen, Goren, Alon, Mostoslavsky, Raul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
https://ncbi.nlm.nih.gov/pubmed/31399344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.034
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