The histone deacetylase SIRT6 restrains transcription elongation via promoter- proximal pausing

Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA Polymerase II (Pol II) pauses before proceeding towards productive elongation. The role of chromatin in pausing remains poorly understood. Here, we demonstrate that the histone deacetyl...

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Pubblicato in:Mol Cell
Autori principali: Etchegaray, Jean-Pierre, Zhong, Lei, Li, Catherine, Henriques, Telmo, Ablondi, Eileen, Nakadai, Tomoyoshi, Van Rechem, Capucine, Ferrer, Christina, Ross, Kenneth N., Choi, Jee-Eun, Samarakkody, Ann, Ji, Fei, Chang, Andrew, Sadreyev, Ruslan I., Ramaswamy, Sridhar, Nechaev, Sergei, Whetstine, Johnathan R., Roeder, Robert G., Adelman, Karen, Goren, Alon, Mostoslavsky, Raul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
https://ncbi.nlm.nih.gov/pubmed/31399344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.034
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