The histone deacetylase SIRT6 restrains transcription elongation via promoter- proximal pausing

Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA Polymerase II (Pol II) pauses before proceeding towards productive elongation. The role of chromatin in pausing remains poorly understood. Here, we demonstrate that the histone deacetyl...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Etchegaray, Jean-Pierre, Zhong, Lei, Li, Catherine, Henriques, Telmo, Ablondi, Eileen, Nakadai, Tomoyoshi, Van Rechem, Capucine, Ferrer, Christina, Ross, Kenneth N., Choi, Jee-Eun, Samarakkody, Ann, Ji, Fei, Chang, Andrew, Sadreyev, Ruslan I., Ramaswamy, Sridhar, Nechaev, Sergei, Whetstine, Johnathan R., Roeder, Robert G., Adelman, Karen, Goren, Alon, Mostoslavsky, Raul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
https://ncbi.nlm.nih.gov/pubmed/31399344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.034
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