Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes

Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer with few effective treatments and the underlying mechanisms that drive HCC pathogenesis remain poorly characterized. Identifying genes and pathways essential for HCC cell growth will aid the development of new targeted therapies...

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Veröffentlicht in:Hepatology
Hauptverfasser: Kwan, Suet-Yan, Sheel, Ankur, Song, Chun-Qing, Zhang, Xiao-Ou, Jiang, Tingting, Dang, Hien, Cao, Yueying, Ozata, Deniz M., Mou, Haiwei, Yin, Hao, Weng, Zhiping, Wang, Xin Wei, Xue, Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906267/
https://ncbi.nlm.nih.gov/pubmed/31188495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30807
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