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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
Defects in p53 function, which occur frequently in human cancers due to mutations in TP53 or disruptions in the p53 regulatory pathway, render cells dependent on CHK1 (Checkpoint Kinase 1) to activate cell cycle checkpoints. In the presence of DNA damage or replication stress, inhibition of CHK1 lea...
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| Udgivet i: | Trends Mol Med |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6905465/ https://ncbi.nlm.nih.gov/pubmed/21087899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2010.10.009 |
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