Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

Patients with triple-negative breast cancer (TNBC) — defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human epidermal growth factor receptor 2 (HER2) amplification — have a poor prognosis. There is a need for targeted therapies to treat this condition. TNB...

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Main Authors: Ma, Cynthia X., Cai, Shirong, Li, Shunqiang, Ryan, Christine E., Guo, Zhanfang, Schaiff, W. Timothy, Lin, Li, Hoog, Jeremy, Goiffon, Reece J., Prat, Aleix, Aft, Rebecca L., Ellis, Matthew J., Piwnica-Worms, Helen
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314455/
https://ncbi.nlm.nih.gov/pubmed/22446188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58765
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