Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn(2+) is decreased. In old transgenic mice expressing mutated human (APP(SwInd)) linked to Familial Al...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Main Authors: Medina, Christopher S., Uselman, Taylor W., Barto, Daniel R., Cháves, Frances, Jacobs, Russell E., Bearer, Elaine L.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901799/
https://ncbi.nlm.nih.gov/pubmed/31849608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00501
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