Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn(2+) is decreased. In old transgenic mice expressing mutated human (APP(SwInd)) linked to Familial Al...

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Publicado en:Front Cell Neurosci
Autores principales: Medina, Christopher S., Uselman, Taylor W., Barto, Daniel R., Cháves, Frances, Jacobs, Russell E., Bearer, Elaine L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901799/
https://ncbi.nlm.nih.gov/pubmed/31849608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00501
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