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Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn(2+) is decreased. In old transgenic mice expressing mutated human (APP(SwInd)) linked to Familial Al...

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Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Medina, Christopher S., Uselman, Taylor W., Barto, Daniel R., Cháves, Frances, Jacobs, Russell E., Bearer, Elaine L.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901799/
https://ncbi.nlm.nih.gov/pubmed/31849608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00501
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