Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn(2+) is decreased. In old transgenic mice expressing mutated human (APP(SwInd)) linked to Familial Al...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Neurosci
Päätekijät: Medina, Christopher S., Uselman, Taylor W., Barto, Daniel R., Cháves, Frances, Jacobs, Russell E., Bearer, Elaine L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901799/
https://ncbi.nlm.nih.gov/pubmed/31849608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00501
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