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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile plaques are located in proximity to nerve processes. The principal component of this extracellular amyloid is beta/A4, a peptide derived from a larger amyloid precursor protein (APP), which is actively express...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Koo, E H, Sisodia, S S, Archer, D R, Martin, L J, Weidemann, A, Beyreuther, K, Fischer, P, Masters, C L, Price, D L
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53515/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1689489/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.4.1561
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