Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

The precursor of the Alzheimer's disease-specific amyloid A4 protein is an integral, glycosylated membrane protein which spans the bilayer once. The carboxy-terminal domain of 47 residues was located at the cytoplasmic site of the membrane. The three domains following the transient signal seque...

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Veröffentlicht in:EMBO J
Hauptverfasser: Dyrks, T, Weidemann, A, Multhaup, G, Salbaum, J M, Lemaire, H G, Kang, J, Müller-Hill, B, Masters, C L, Beyreuther, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1988
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2900137/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb02900.x
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