Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

The precursor of the Alzheimer's disease-specific amyloid A4 protein is an integral, glycosylated membrane protein which spans the bilayer once. The carboxy-terminal domain of 47 residues was located at the cytoplasmic site of the membrane. The three domains following the transient signal sequence o...

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Publicado en:	EMBO J
Autores principales:	Dyrks, T, Weidemann, A, Multhaup, G, Salbaum, J M, Lemaire, H G, Kang, J, Müller-Hill, B, Masters, C L, Beyreuther, K
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 1988
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2900137/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb02900.x
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