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Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain
Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn(2+) is decreased. In old transgenic mice expressing mutated human (APP(SwInd)) linked to Familial Al...
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| 出版年: | Front Cell Neurosci |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901799/ https://ncbi.nlm.nih.gov/pubmed/31849608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00501 |
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