Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA

Ribonucleotides are the most common non-canonical nucleotides incorporated into DNA during replication, and their processing leads to mutations and genome instability. Yeast mutation reporter systems demonstrate that 2–5 base pair deletions (Δ2–5bp) in repetitive DNA are a signature of unrepaired ri...

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Veröffentlicht in:DNA Repair (Amst)
Hauptverfasser: Williams, Jessica S., Lujan, Scott A., Zhou, Zhi-Xiong, Burkholder, Adam B., Clark, Alan B., Fargo, David C., Kunkel, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901746/
https://ncbi.nlm.nih.gov/pubmed/31311768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102641
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