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Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA

Ribonucleotides are the most common non-canonical nucleotides incorporated into DNA during replication, and their processing leads to mutations and genome instability. Yeast mutation reporter systems demonstrate that 2–5 base pair deletions (Δ2–5bp) in repetitive DNA are a signature of unrepaired ri...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:DNA Repair (Amst)
Egile Nagusiak: Williams, Jessica S., Lujan, Scott A., Zhou, Zhi-Xiong, Burkholder, Adam B., Clark, Alan B., Fargo, David C., Kunkel, Thomas A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901746/
https://ncbi.nlm.nih.gov/pubmed/31311768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102641
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