Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA

Ribonucleotides are the most common non-canonical nucleotides incorporated into DNA during replication, and their processing leads to mutations and genome instability. Yeast mutation reporter systems demonstrate that 2–5 base pair deletions (Δ2–5bp) in repetitive DNA are a signature of unrepaired ri...

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Bibliografische gegevens
Gepubliceerd in:DNA Repair (Amst)
Hoofdauteurs: Williams, Jessica S., Lujan, Scott A., Zhou, Zhi-Xiong, Burkholder, Adam B., Clark, Alan B., Fargo, David C., Kunkel, Thomas A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901746/
https://ncbi.nlm.nih.gov/pubmed/31311768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102641
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