Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. However, an understanding of their specific functions has been hampered by an inability to synthesize large numbers of diverse, yet defined, HS structures. Here, w...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Pawar, Nitin J., Wang, Lei, Higo, Takuya, Bhattacharya, Chandrabali, Kancharla, Pavan K., Zhang, Fuming, Baryal, Kedar, Huo, Chang-Xin, Liu, Jian, Linhardt, Robert J., Huang, Xuefei, Hsieh-Wilson, Linda C.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901730/
https://ncbi.nlm.nih.gov/pubmed/31553820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201908805
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