Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. However, an understanding of their specific functions has been hampered by an inability to synthesize large numbers of diverse, yet defined, HS structures. Here, w...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Pawar, Nitin J., Wang, Lei, Higo, Takuya, Bhattacharya, Chandrabali, Kancharla, Pavan K., Zhang, Fuming, Baryal, Kedar, Huo, Chang-Xin, Liu, Jian, Linhardt, Robert J., Huang, Xuefei, Hsieh-Wilson, Linda C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901730/
https://ncbi.nlm.nih.gov/pubmed/31553820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201908805
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