The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS proto-oncogene 1 (ETS1) and associated with overexpression of BCL...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., Guicciardi, Maria Eugenia, Splinter, Noah P., Al Suraih, Mohammed S., Nasser-Ghodsi, Navine, Stollenwerk, Deborah, Gores, Gregory J., LaRusso, Nicholas F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2019
Θέματα:
Molecular Bases of Disease
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901313/
https://ncbi.nlm.nih.gov/pubmed/31659122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010176
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