ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A

Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (disease of the bile ducts) of unknown pathogenesis. We reported that cholangiocyte senescence features prominently in PSC and that neuroblastoma RAS viral oncogene homolog (NRAS) is activated in PSC cholangiocytes....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., Pisarello, Maria J. Lorenzo, Loarca, Lorena, Splinter, Noah S., Schutte, Bryce F., LaRusso, Nicholas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377799/
https://ncbi.nlm.nih.gov/pubmed/28184004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777409
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