The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS proto-oncogene 1 (ETS1) and associated with overexpression of BCL...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., Guicciardi, Maria Eugenia, Splinter, Noah P., Al Suraih, Mohammed S., Nasser-Ghodsi, Navine, Stollenwerk, Deborah, Gores, Gregory J., LaRusso, Nicholas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901313/
https://ncbi.nlm.nih.gov/pubmed/31659122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010176
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