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The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS proto-oncogene 1 (ETS1) and associated with overexpression of BCL...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., Guicciardi, Maria Eugenia, Splinter, Noah P., Al Suraih, Mohammed S., Nasser-Ghodsi, Navine, Stollenwerk, Deborah, Gores, Gregory J., LaRusso, Nicholas F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901313/
https://ncbi.nlm.nih.gov/pubmed/31659122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010176
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