Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2(−/−) mice

Cholangiocyte senescence has been linked to primary sclerosing cholangitis (PSC). Persistent secretion of growth factors by senescent cholangiocytes leads to the activation of stromal fibroblasts (ASF), which are drivers of fibrosis. The activated phenotype of ASF is characterized by an increased se...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Moncsek, Anja, Al-Suraih, Mohammed S., Trussoni, Christy E., O’Hara, Steven P., Splinter, Patrick L., Zuber, Camille, Patsenker, Eleonora, Valli, Piero V., Fingas, Christian D., Weber, Achim, Zhu, Yi, Tchkonia, Tamar, Kirkland, James L., Gores, Gregory J., Müllhaupt, Beat, LaRusso, Nicholas F., Mertens, Joachim C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739965/
https://ncbi.nlm.nih.gov/pubmed/28802066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29464
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker