Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2(−/−) mice

Cholangiocyte senescence has been linked to primary sclerosing cholangitis (PSC). Persistent secretion of growth factors by senescent cholangiocytes leads to the activation of stromal fibroblasts (ASF), which are drivers of fibrosis. The activated phenotype of ASF is characterized by an increased se...

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Publicado no:Hepatology
Main Authors: Moncsek, Anja, Al-Suraih, Mohammed S., Trussoni, Christy E., O’Hara, Steven P., Splinter, Patrick L., Zuber, Camille, Patsenker, Eleonora, Valli, Piero V., Fingas, Christian D., Weber, Achim, Zhu, Yi, Tchkonia, Tamar, Kirkland, James L., Gores, Gregory J., Müllhaupt, Beat, LaRusso, Nicholas F., Mertens, Joachim C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739965/
https://ncbi.nlm.nih.gov/pubmed/28802066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29464
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