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RNA base-pairing complexity in living cells visualized by correlated chemical probing

RNA structure and dynamics are critical to biological function. However, strategies for determining RNA structure in vivo are limited, with established chemical probing and newer duplex detection methods each having deficiencies. Here we convert the common reagent dimethyl sulfate into a useful prob...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mustoe, Anthony M., Lama, Nicole N., Irving, Patrick S., Olson, Samuel W., Weeks, Kevin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900531/
https://ncbi.nlm.nih.gov/pubmed/31744869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905491116
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