RNA base-pairing complexity in living cells visualized by correlated chemical probing

RNA structure and dynamics are critical to biological function. However, strategies for determining RNA structure in vivo are limited, with established chemical probing and newer duplex detection methods each having deficiencies. Here we convert the common reagent dimethyl sulfate into a useful prob...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mustoe, Anthony M., Lama, Nicole N., Irving, Patrick S., Olson, Samuel W., Weeks, Kevin M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900531/
https://ncbi.nlm.nih.gov/pubmed/31744869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905491116
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