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RNA base-pairing complexity in living cells visualized by correlated chemical probing

RNA structure and dynamics are critical to biological function. However, strategies for determining RNA structure in vivo are limited, with established chemical probing and newer duplex detection methods each having deficiencies. Here we convert the common reagent dimethyl sulfate into a useful prob...

Полное описание

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Mustoe, Anthony M., Lama, Nicole N., Irving, Patrick S., Olson, Samuel W., Weeks, Kevin M.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900531/
https://ncbi.nlm.nih.gov/pubmed/31744869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905491116
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