Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

In bone, sclerostin is mainly osteocyte‐derived and plays an important local role in adaptive responses to mechanical loading. Whether circulating levels of sclerostin also play a functional role is currently unclear, which we aimed to examine by two‐sample Mendelian randomization (MR). A genetic in...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Bone Miner Res
المؤلفون الرئيسيون: Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus, Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M, Medina‐Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young‐Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H, Nilsson, Karin H, Movérare‐Skrtic, Sofia, Baird, Denis, Elsworth, Benjamin, Falk, Louise, Groom, Alix, Capellini, Terence D, Grundberg, Elin, Nethander, Maria, Ohlsson, Claes, Davey Smith, George, Tobias, Jonathan H
التنسيق: Artigo
اللغة:Inglês
منشور في: John Wiley and Sons Inc. 2019
الموضوعات:
Original Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899787/
https://ncbi.nlm.nih.gov/pubmed/31170332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3803
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة