Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

In bone, sclerostin is mainly osteocyte‐derived and plays an important local role in adaptive responses to mechanical loading. Whether circulating levels of sclerostin also play a functional role is currently unclear, which we aimed to examine by two‐sample Mendelian randomization (MR). A genetic in...

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Bibliografiske detaljer
Udgivet i:J Bone Miner Res
Main Authors: Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus, Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M, Medina‐Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young‐Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H, Nilsson, Karin H, Movérare‐Skrtic, Sofia, Baird, Denis, Elsworth, Benjamin, Falk, Louise, Groom, Alix, Capellini, Terence D, Grundberg, Elin, Nethander, Maria, Ohlsson, Claes, Davey Smith, George, Tobias, Jonathan H
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899787/
https://ncbi.nlm.nih.gov/pubmed/31170332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3803
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