Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

In bone, sclerostin is mainly osteocyte‐derived and plays an important local role in adaptive responses to mechanical loading. Whether circulating levels of sclerostin also play a functional role is currently unclear, which we aimed to examine by two‐sample Mendelian randomization (MR). A genetic in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus, Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M, Medina‐Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young‐Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H, Nilsson, Karin H, Movérare‐Skrtic, Sofia, Baird, Denis, Elsworth, Benjamin, Falk, Louise, Groom, Alix, Capellini, Terence D, Grundberg, Elin, Nethander, Maria, Ohlsson, Claes, Davey Smith, George, Tobias, Jonathan H
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899787/
https://ncbi.nlm.nih.gov/pubmed/31170332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3803
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados