Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

BACKGROUND: Using high-dimensional penalized regression we studied genome-wide DNA-methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral density (BMD). The women showed BMD varying from severely osteoporotic to normal. Global gene expression data from the same ind...

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Udgivet i:BMC Med Genomics
Main Authors: Lien, Tonje G., Borgan, Ørnulf, Reppe, Sjur, Gautvik, Kaare, Glad, Ingrid Kristine
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842543/
https://ncbi.nlm.nih.gov/pubmed/29514638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0341-2
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