Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

BACKGROUND: Using high-dimensional penalized regression we studied genome-wide DNA-methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral density (BMD). The women showed BMD varying from severely osteoporotic to normal. Global gene expression data from the same ind...

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Dettagli Bibliografici
Pubblicato in:BMC Med Genomics
Autori principali: Lien, Tonje G., Borgan, Ørnulf, Reppe, Sjur, Gautvik, Kaare, Glad, Ingrid Kristine
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842543/
https://ncbi.nlm.nih.gov/pubmed/29514638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0341-2
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