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Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation

BACKGROUND AND AIM: Overdose of acetaminophen (APAP) leads to liver injury, which is one of the most common causes of liver failure in the United States. We previously demonstrated that pharmacological activation of autophagy protects against APAP-induced liver injury in mice via removal of damaged...

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Vydáno v:Liver Res
Hlavní autoři: Li, Yuan, Ni, Hong-Min, Jaeschke, Hartmut, Ding, Wen-Xing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897503/
https://ncbi.nlm.nih.gov/pubmed/31815033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.livres.2019.01.004
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