Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function

The conserved eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) removes a diverse array of adducts from the end of DNA strand breaks. Tdp1 specifically catalyzes the hydrolysis of phosphodiester linked DNA-adducts. These DNA lesions range from damaged nucleotides to peptide-DNA add...

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Udgivet i:Genes (Basel)
Main Authors: Brettrager, Evan J., Segura, Isaac A., van Waardenburg, Robert C. A. M.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895789/
https://ncbi.nlm.nih.gov/pubmed/31698852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10110897
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