Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis

Tyrosyl-DNA phosphodiesterase I (TDP1), like most DNA repair associated proteins, is not essential for cell viability. However, dysfunctioning TDP1 or ATM (ataxia telangiectasia mutated) results in autosomal recessive neuropathology with similar phenotypes, including cerebellar atrophy. Dual inactiv...

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Vydáno v:J Neurol Neuromedicine
Hlavní autor: van Waardenburg, Robert C.A.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064944/
https://ncbi.nlm.nih.gov/pubmed/27747316
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