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Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis

Tyrosyl-DNA phosphodiesterase I (TDP1), like most DNA repair associated proteins, is not essential for cell viability. However, dysfunctioning TDP1 or ATM (ataxia telangiectasia mutated) results in autosomal recessive neuropathology with similar phenotypes, including cerebellar atrophy. Dual inactiv...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurol Neuromedicine
Prif Awdur: van Waardenburg, Robert C.A.M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064944/
https://ncbi.nlm.nih.gov/pubmed/27747316
Tagiau: Ychwanegu Tag
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